Publications
Preprints
Annotation: *equal contribution, #co-corresponding author; self; mentee
40. Shasha C, Glass DR, Moelhman E, Islas L, Tian Y, Szeto GL, Peng T, Song X, Wurscher M, Bumol TF, Torgerson TR, Greenberg PD, Green DJ, Newell EW. Hallmarks of tumor-experienced T cells are absent in multiple myeloma patients from diagnosis through maintenance therapy. bioRxiv [Preprint]. 2024 Jun 4:2024.06.03.597178. doi: 10.1101/2024.06.03.597178. PMID: 38895348; PMCID: PMC11185627.
2024
39. Ritzel RM, Li Y, Jiao Y, Doran SJ, Khan N, Henry RJ, Brunner K, Loane DJ, Faden AI, Szeto GL, Wu J. Bi-directional neuro-immune dysfunction after chronic experimental brain injury. J Neuroinflammation. 2024 Apr 5;21(1):83. doi: 10.1186/s12974-024-03082-y.
38. Collins JM, Lang A, Parisi C, Moharrer Y, Nijsure MP, Thomas Kim JH, Ahmed S, Szeto GL, Qin L, Gottardi R, Dyment NA, Nowlan NC, Boerckel JD. YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development. Dev Cell. 2024 Jan 22;59(2):211-227.e5. doi: 10.1016/j.devcel.2023.11.029.
2023
37. Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nat Immunol. 2023 Nov;24(11):1947-1959. doi: 10.1038/s41590-023-01641-8.
36. Talla A*, Vasaikar SV*, Szeto GL, Lemos MP, Czartoski JL, MacMillan H, Moodie Z, Cohen KW, Fleming LB, Thomson Z, Okada L, Becker LA, Coffey EM, De Rosa SC, Newell EW, Skene PJ, Li X, Bumol TF, Juliana McElrath M, Torgerson TR. Persistent serum protein signatures define an inflammatory subcategory of long COVID. Nat Commun. 2023 Jun 9;14(1):3417. doi: 10.1038/s41467-023-38682-4.
35. Zhang MH, Scotland BL, Jiao Y, Slaby EM, Truong N, Cottingham AL, Stephanie G, Szeto GL#, Pearson RM#. Lipid-Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to Elicit Distinct Antigen-Specific CD4+ and CD8+ T Cell Responses. ACS Appl Bio Mater. 2023 May 23:10.1021/acsabm.3c00229. doi: 10.1021/acsabm.3c00229.
34. Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Szeto GL, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 Apr 19;14(4):252-257. doi: 10.1016/j.cels.2023.03.002. PMID: 37080161; PMCID: PMC10760508.
33. Ritzel RM, Li Y, Jiao Y, Lei Z, Doran SJ, He J, Shahror RA, Henry RJ, Khan R, Tan C, Liu S, Stoica BA, Faden AI, Szeto G, Loane DJ, Wu J. Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration. Sci Adv. 2023 Mar 10;9(10):eadd1101. doi: 10.1126/sciadv.add1101.
2022
32. Jeon M, Chauhan KM, Szeto GL, Kyoung M, An S. Subcellular regulation of glucose metabolism through multienzyme glucosome assemblies by EGF-ERK1/2 signaling pathways. J Biol Chem. 2022. doi: /10.1016/j.jbc.2022.101675
2021
31. Allen ME, Golding A, Rus V, Karabin NB, Li S, Lescott CJ, Bobbala S, Scott EA, Szeto GL#. Targeted Delivery of Chloroquine to Antigen-Presenting Cells Enhances Inhibition of the Type I Interferon Response. ACS Biomater Sci Eng. 2021 Nov 23. doi: 10.1021/acsbiomaterials.1c01047. Epub ahead of print. PMID: 34813288.
30. Rando HM, MacLean AL, Lee AJ, Lordan R, Ray S, Bansal V, Skelly AN, Sell E, Dziak JJ, Shinholster L, D'Agostino McGowan L, Ben Guebila M, Wellhausen N, Knyazev S, Boca SM, Capone S, Qi Y, Park Y, Mai D, Sun Y, Boerckel JD, Brueffer C, Byrd JB, Kamil JP, Wang J, Velazquez R, Szeto GL, Barton JP, Goel RR, Mangul S, Lubiana T; COVID-19 Review Consortium Vikas Bansal, John P. Barton, Simina M. Boca, Joel D. Boerckel, Christian Brueffer, James Brian Byrd, Stephen Capone, Shikta Das, Anna Ada Dattoli, John J. Dziak, Jeffrey M. Field, Soumita Ghosh, Anthony Gitter, Rishi Raj Goel, Casey S. Greene, Marouen Ben Guebila, Daniel S. Himmelstein, Fengling Hu, Nafisa M. Jadavji, Jeremy P. Kamil, Sergey Knyazev, Likhitha Kolla, Alexandra J. Lee, Ronan Lordan, Tiago Lubiana, Temitayo Lukan, Adam L. MacLean, David Mai, Serghei Mangul, David Manheim, Lucy D’Agostino McGowan, Amruta Naik, YoSon Park, Dimitri Perrin, Yanjun Qi, Diane N. Rafizadeh, Bharath Ramsundar, Halie M. Rando, Sandipan Ray, Michael P. Robson, Vincent Rubinetti, Elizabeth Sell, Lamonica Shinholster, Ashwin N. Skelly, Yuchen Sun, Yusha Sun, Gregory L. Szeto, Ryan Velazquez, Jinhui Wang, Nils Wellhausen,, Gitter A, Greene CS. Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure. mSystems. 2021 Oct 26;6(5):e0009521. doi: 10.1128/mSystems.00095-21. Epub 2021 Oct 26. PMID: 34698547; PMCID: PMC8547481.
29. Allen ME, Rus V, Szeto GL#. Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies. Trends Mol Med. 2021 Feb;27(2):152-171. doi: 10.1016/j.molmed.2020.09.009. Epub 2020 Oct 9. PMID: 33046407.
2020
28. Burgenson D, Linton J, Ge X, Kostov Y, Tolosa L, Szeto GL, Rao G. A Cell-Free Protein Expression System Derived from Human Primary Peripheral Blood Mononuclear Cells. ACS Synth Biol. 2020 Aug 21;9(8):2188-2196. doi: 10.1021/acssynbio.0c00256. Epub 2020 Aug 6. PMID: 32698572.
27. Simpson LW, Szeto GL, Boukari H, Good TA, Leach JB. Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects. Acta Biomater. 2020 Aug;112:164-173. doi: 10.1016/j.actbio.2020.05.030. Epub 2020 May 25. PMID: 32464268.
26. Zhang MH, Slaby EM, Stephanie G, Yu C, Watts DM, Liu H, Szeto GL#. Lipid-Mediated Insertion of Toll-Like Receptor (TLR) Ligands for Facile Immune Cell Engineering. Front Immunol. 2020 Apr 22;11:560. doi: 10.3389/fimmu.2020.00560. PMID: 32425924; PMCID: PMC7212467.
25. Henry RJ, Ritzel RM, Barrett JP, Doran SJ, Jiao Y, Leach JB, Szeto GL, Wu J, Stoica BA, Faden AI, Loane DJ. Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits. J Neurosci. 2020 Apr 1;40(14):2960-2974. doi: 10.1523/JNEUROSCI.2402-19.2020. Epub 2020 Feb 24. PMID: 32094203; PMCID: PMC7117897.
24. Stampouloglou E, Cheng N, Federico A, Slaby E, Monti S, Szeto GL#, Varelas X*#. Yap suppresses T-cell function and infiltration in the tumor microenvironment. PLoS Biol. 2020 Jan 13;18(1):e3000591. doi: 10.1371/journal.pbio.3000591. PMID: 31929526; PMCID: PMC6980695.
2019-2016
23. Szeto GL#, Finley SD*#. Integrative Approaches to Cancer Immunotherapy. Trends Cancer. 2019 Jul;5(7):400-410. doi: 10.1016/j.trecan.2019.05.010. PMID: 31311655; PMCID: PMC7467854.
22. Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD. Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy. Cell Rep. 2016 Dec 6;17(10):2503-2511. doi: 10.1016/j.celrep.2016.11.020. PMID: 27926855; PMCID: PMC5204262.
21. Moynihan KD*, Opel CF*, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24. PMID: 27775706; PMCID: PMC5209798.
20. ImmunoExplorer: A Web-Based Multivariate Visualization System for Exploratory Analysis of Immunotherapy
19. Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark NR, Jones MR, Kou Y, Goff T, Woodland H, Amaral FMR, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bausela XB, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dishuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Dae Devlin T, Pérez-García V, Ma'ayan A. Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd. Nat Commun. 2016 Sep 26;7:12846. doi: 10.1038/ncomms12846. PMID: 27667448; PMCID: PMC5052684.
18. Szeto GL#, Lavik EB#. Materials design at the interface of nanoparticles and innate immunity. J Mater Chem B. 2016 Mar 7;4(9):1610-1618. doi: 10.1039/C5TB01825K. Epub 2016 Jan 29. PMID: 27453783; PMCID: PMC4950994.
17. Kimmerling RJ, Szeto GL, Li JW, Genshaft AS, Kazer SW, Payer KR, de Riba Borrajo J, Blainey PC, Irvine DJ, Shalek AK, Manalis SR. A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun. 2016 Jan 6;7:10220. doi: 10.1038/ncomms10220. PMID: 26732280; PMCID: PMC4729820.
2015 and earlier
16. Arnold KB*, Szeto GL*, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Sci Signal. 2015 Oct 20;8(399):ra104. doi: 10.1126/scisignal.aab0808. PMID: 26486173; PMCID: PMC4634873.
15. Szeto GL, Van Egeren D, Worku H, Sharei A, Alejandro B, Park C, Frew K, Brefo M, Mao S, Heimann M, Langer R, Jensen K, Irvine DJ. Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines. Sci Rep. 2015 May 22;5:10276. doi: 10.1038/srep10276. PMID: 25999171; PMCID: PMC4441198.
14. Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants. J Clin Invest. 2015 Jun;125(6):2532-46. doi: 10.1172/JCI79915. Epub 2015 May 4. PMID: 25938786; PMCID: PMC4497758.
13. Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ. Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides. Vaccine. 2015 Feb 11;33(7):861-8. doi: 10.1016/j.vaccine.2014.12.045. Epub 2015 Jan 2. PMID: 25559188; PMCID: PMC4312707.
12. Castellarnau M*, Szeto GL*, Su HW, Tokatlian T, Love JC, Irvine DJ, Voldman J. Stochastic particle barcoding for single-cell tracking and multiparametric analysis. Small. 2015 Jan 27;11(4):489-98. doi: 10.1002/smll.201401369. Epub 2014 Sep 2. PMID: 25180800; PMCID: PMC4303509.
11. Jones RB, O'Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 2014 Aug 14;10(8):e1004287. doi: 10.1371/journal.ppat.1004287. PMID: 25122219; PMCID: PMC4133386.
10. Drewes JL, Szeto GL, Engle EL, Liao Z, Shearer GM, Zink MC, Graham DR. Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline. PLoS One. 2014 Apr 14;9(4):e94375. doi: 10.1371/journal.pone.0094375. PMID: 24732038; PMCID: PMC3986096.
9. Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 2014 Mar 27;507(7493):519-22. doi: 10.1038/nature12978. Epub 2014 Feb 16. PMID: 24531764; PMCID: PMC4069155.
8. Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, Irvine DJ. Koch Institute Symposium on Cancer Immunology and Immunotherapy. Cancer Immunol Res. 2013 Oct;1:217-222. doi: 10.1158/2326-6066.CIR-13-0116. PMID: 24466562; PMCID: PMC3897860. (REVIEW)
7. Irvine DJ, Swartz MA, Szeto GL. Engineering synthetic vaccines using cues from natural immunity. Nat Mater. 2013 Nov;12(11):978-90. doi: 10.1038/nmat3775. PMID: 24150416; PMCID: PMC3928825. (REVIEW)
6. Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MS, Lauffenburger DA, Irvine DJ, Love JC. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Anal Chem. 2012 Dec 18;84(24):10531-6. doi: 10.1021/ac302264q. Epub 2012 Dec 3. PMID: 23205933; PMCID: PMC3691955.
5. Szeto GL, Pomerantz JL, Graham DR, Clements JE. Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells. J Biol Chem. 2011 Apr 1;286(13):11275-82. doi: 10.1074/jbc.M110.210518. Epub 2011 Jan 31. PMID: 21282105; PMCID: PMC3064183.
4. Szeto GL, Brice AK, Yang HC, Barber SA, Siliciano RF, Clements JE. Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells. J Infect Dis. 2010 Apr 15;201(8):1132-40. doi: 10.1086/651277. PMID: 20205570; PMCID: PMC3739045.
3. Battlefield decision aid for acoustical ground sensors with interface to meteorological data sources
2. Wilson DK, Szeto GL, VanAartsen BH, Noble JM. A Prototype Acoustic Battlefield Decision Aid with Interfaces to Meteorological Data Sources and a Target Database.
1. Wilson DK, Szeto GL. 2000. Reference guide for the acoustic battlefield aid (ABFA) version 2. Army Research Laboratory Technical Report ARL-TR-2159