Publications

  1. Moynihan KD*, Opel CF*, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kwan BH, Abraham W, Hu K, Kauke MJ, Suh H, Lauffenburger DA, Wittrup KD, Irvine DJ. “Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.” Nature Medicine. 24 Oct 2016. doi: 10.1038/nm.4200

    MIT News Article: Fighting cancer with the power of immunity
    Nature: Multi-pronged tumour attack
    G
    EN News HighlightsLarge Tumors Destroyed by Innate/Adaptive Immunotherapy Combo
    FierceBiotech: Targeting both immune system branches could be key for cancer immunotherapy

  2. Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard A, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark N, Jones M, Kou Y, Goff T, Woodland H, Amaral F, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bengoetxea X, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dischuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Devlin TD, Pérez-García V, Ma’ayan A. “Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd.” Nature Communications.  2016 Sept 26. doi: 10.1038/ncomms12846
    Mt. Sinai news article: Crowdsourcing for Scientific Discovery: Mount Sinai Researchers Find Novel Ways to Analyze Data for Drug and Target Discovery

  3. Szeto GL, Lavik EB. “Materials design at the interface of nanoparticles and innate immunity.” Journal of Materials Chemistry B. 27 Jan 2016. doi: 10.1039/C5TB01825K

  4. Kimmerling R, Szeto GL, Li J, Genshaft A, Kazer S, Borrajo J, Blainey P, Irvine DJ, Shalek A, Manalis SR. “A microfluidic platform enabling single cell RNA-seq of multigenerational lineages.” Nature Communications. 2016 Jan 6. doi: 10.1038/ncomms10220
    MIT News Article: Tracing a cellular family tree

  5. Arnold KB*, Szeto GL*, Alter G, Irvine DJ, Lauffenburger DA. “CD4+ T Cell-Dependent and -Independent Cytokine/Chemokine Network Changes in Immune Responses of HIV-infected Individuals.” Science Signaling. 2015 Oct 20. doi: 10.1126/scisignal.aab0808.
    Cover Image/Featured Article; Read Abstract or Free Full Text

  6. Szeto GL, Van Egeren D, Worku H, Sharei A, Alejandro B, Park C, Frew K, Brefo M, Mao S, Heimann M, Langer R, Jensen K, Irvine DJ. “Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines.” Scientific Reports. 2015 May 22. doi: 10.1038/srep10276.
    MIT News article: Freshly squeezed vaccines; Spotlight Image, 2015 May 26
; Roche invests $500M with SQZ for our B cell pipeline/vision

  7. Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. “Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants.” The Journal of Clinical Investigation. 2015 May 4. doi: 10.1172/JCI79915.

  8. Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ. “Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides.” Vaccine. 2015 Jan 2. doi: 10.1016/j.vaccine.2014.12.045.

  9. Castellarnau M*, Szeto GL*, Su H-W, Love JC, Irvine DJ, Voldman J. “Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis.” Small. 2014 Sep 2. doi: 10.1002/smll.201401369.

  10. Jones RB, O’Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. “Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes.” PLoS Pathog. 2014 Aug 14;10(8):e1004287. doi: 10.1371/journal.ppat.1004287.

  11. Drewes J, Szeto GL, Liao Z, Shearer GM, Zink MC, Graham DRM. “Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.” PLoS ONE. 2014 Apr;9(4):e94375. doi: 10.1371/journal.pone.0094375.

  12. Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. “Structure-based programming of lymph-node targeting in molecular vaccines.” Nature. 2014 Feb 16. doi: 10.1038/nature12978.
Faculty of 1000 Prime Recommendations

  13. Irvine DJ, Swartz MA, Szeto GL. “Engineering synthetic vaccines using cues from natural immunity.”
    Nat Mater. 2013 Nov;12(11):978-90. doi: 10.1038/nmat3775.

  14. Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, Irvine DJ. “Koch Institute Symposium on Cancer Immunology and Immunotherapy.” Cancer Immunol Res. 2013 Oct;1:217-222. doi: 10.1158/2326-6066.CIR-13-0116.

  15. Yamanaka YJ*, Szeto GL*, Gierahn T, Forcier T, Benedict KF, Brefo M, Lauffenburger DA, Irvine DJ, Love JC. “Cellular Barcodes for Efficiently Profiling Single-Cell Secretory Responses by Microengraving.”
    Anal Chem. 2012 Dec 18;84(24):10531-6. doi: 10.1021/ac302264q. Epub 2012 Dec 3.

  16. Szeto GL, Pomerantz JL, Graham DRM, Clements JE. “Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells.” J Biol Chem. 2011 Apr 1;286(13):11275-82. doi: 10.1074/jbc.M110.210518. Epub 2011 Jan 31.

  17. Szeto GL, Brice AK, Yang HC, Barber SA, Siliciano RF, Clements JE. “Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells.” J Infect Dis. 2010 Apr 15;201(8):1132-40. doi: 10.1086/651277.
    
Editorial commentary: J Infect Dis. 2010 Apr 15;201(8):1115-1116.
    Faculty of 1000 Prime Recommendations

  18. Wilson DK, Szeto GL, Van Aartsen BH, Noble JM. “A Prototype Acoustic Battlefield Decision Aid with Interfaces to Meteorological Data Sources and a Target Database.” DoD Technical Report # A231293, Oct 2000.

Patents

  1. “Methods and Applications for Loading Biomolecules into Immune Cell Plasma Membranes.”

    Szeto GL, Irvine DJ, Van Egeren DS, Zhang MH. Disclosure submitted to MIT on May 28, 2015.

  2. “Delivery of Biomolecules to Immune Cells.”

    Sharei AR, Mao S, Hartoularos G, Liu S, Heimann M, Basto P, Szeto GL, Jhunjhunwala S, Irvine DJ, Langer RS, Jensen KF. US Provisional Patent # 62/073,548. Filed Oct 31, 2014.

  3. “Method and Apparatus for Tracking Cell Identity.”

    Castellarnau M, Szeto GL, Irvine DJ, Love JC, Voldman J. US Provisional Patent # 14/523,376. Filed Oct 24, 2014.